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Longevity & Bioregulators

Chonluten Australia — Glu-Asp-Gly Tripeptide, 20 mg

Chonluten research peptide vial — TXLABS, ≥98% HPLC

From $99 AUD · ≥98% HPLC purity · third-party COA · ships Australia-wide

What is Chonluten?

Chonluten (Glu-Asp-Gly, EDG) is a synthetic tripeptide bioregulator associated with lung and bronchial tissue. Originally derived from bronchial epithelial peptides, this Khavinson short peptide is investigated in preclinical research on respiratory cell function and gene expression. Chonluten serves as a research reference for pulmonary tissue studies.

Specifications

What the research covers

Chonluten is a synthetic tripeptide, Glu-Asp-Gly, developed within the ultrashort peptide bioregulator programme led by Professor Vladimir Khavinson at the St Petersburg Institute of Bioregulation and Gerontology. It carries the lung and bronchial name in that programme's tissue-based naming scheme, and the respiratory characterisation attached to it was carried out by the originating groups.

Its composition sets it apart chemically from most of the family. Glutamate and aspartate are both acidic; glycine is the smallest and least reactive residue there is. Chonluten therefore has no basic residue at all, which means it carries net negative charge at neutral pH, has a low isoelectric point, and behaves quite differently from the lysine-containing members such as vilon, vesugen and the KED tetrapeptides. That distinction is not cosmetic. It determines how the compound retains on a chromatography column, which ion-pairing reagents are appropriate, how it ionises in a mass spectrometer, and how it behaves in a buffer.

As with every compound in this family, the mechanism advanced in the originating literature is direct peptide interaction with DNA or chromatin-associated proteins producing tissue-selective changes in gene expression, rather than receptor binding. That is a proposal from one research tradition supported mainly by modelling and by that tradition's own studies. It has not been established by independent structural or pharmacological work and this page does not present it as though it had.

The usual caution about the evidence base applies without qualification. The literature is concentrated in a handful of originating laboratories, is largely Russian-language, has accumulated over several decades, and has attracted very limited independent replication.

TXLABS supplies chonluten as a laboratory reference material only. It is not an approved therapeutic good in Australia and is not supplied for human or veterinary administration.

Reading the certificate

Chonluten is the member of this family where the choice of chromatographic method matters most, and a certificate should be read with that in mind. Standard reversed-phase peptide methods use trifluoroacetic acid as an ion-pairing reagent, an approach optimised for cationic peptides; an all-acidic tripeptide gains almost nothing from it and elutes essentially unretained. Anion exchange or hydrophilic interaction chromatography give real separation here, and a certificate showing a single early peak on a generic C18 gradient has not tested the material seriously. Confirm identity by observed mass and check for the deletion species Glu-Asp and Asp-Gly, which are more polar again. TXLABS publishes third-party certificates for tested lots in the CoA library; no certificate is currently published for chonluten, and the certificate for the specific lot supplied is available on request to support@txlabs.bio.

Storage and handling

Two carboxylate side chains and no basic residue make chonluten one of the most hygroscopic materials in the catalogue. The failure mode is not a cake that will not dissolve but one that has already partly dissolved in the air of the room: an acidic short peptide left open on a humid bench will visibly deliquesce, and once that has happened the weighed mass is no longer the peptide mass. Work quickly, equilibrate a cold vial to room temperature sealed before opening it, and reseal with desiccant. Store the dry material at -20 °C, desiccated and dark, and reconstituted solution at 2-8 °C in single-use aliquots. Solubility in water is excellent and needs no assistance. On the Australian transit question, the humid coastal and tropical parts of the country are the genuine hazard for this compound rather than the heat itself, since the vial is sealed in transit but the ambient humidity at the point of opening is what determines whether the powder survives handling.

Working out concentration

Chonluten is stocked in a 20 mg vial. With 2 mL of bacteriostatic water that gives 10 mg/mL; with 4 mL, 5 mg/mL; with 5 mL, 4 mg/mL; with 10 mL, 2 mg/mL. If the material is instead being taken up in a buffer for analytical work, remember that a peptide with two free carboxylates and no basic residue will shift the pH of a weakly buffered solution as it dissolves, so the final pH is worth measuring rather than assuming, particularly at the higher concentrations above. The calculator handles the mass and volume arithmetic. These figures are concentration examples for laboratory record-keeping, not a protocol of any kind.

How it relates to adjacent compounds

Within the family, chonluten's closest sequence neighbour is ovagen, Glu-Asp-Leu, which shares the first two residues and swaps glycine for leucine. That single change makes ovagen markedly more hydrophobic and much harder to dissolve, which is a compact illustration of how much a terminal residue governs the practical chemistry of a tripeptide. Chonluten also shares its tissue name with bronchogen, Ala-Glu-Asp-Leu, a different molecule assigned to the same tissue within the same programme, which is a reminder that these names index a research target rather than a chemical class. Cartalax is the same length with an alanine in place of the terminal glycine's position. Sequence relationships only, with no implication about relative activity.

Frequently asked questions

Why does chonluten behave differently on a standard peptide column? +
Because standard reversed-phase peptide methods are built for cationic analytes. They rely on an acidic mobile phase with trifluoroacetic acid ion-pairing, which improves retention of peptides carrying positive charge. Chonluten has two acidic side chains and no basic residue, so it is negatively charged or neutral under those conditions and gains little retention. It elutes near the void, where separation from salts and other polar species is poor.
What method would characterise it properly? +
Anion exchange chromatography exploits the negative charge directly, and hydrophilic interaction chromatography retains very polar analytes that reversed-phase cannot hold. Either gives genuine separation. Mass spectrometry confirms identity independently, and negative-ion mode often gives a better response for an acidic peptide than positive mode does. A certificate naming the method and the mode tells you far more than a purity number alone.
How hygroscopic is chonluten in practice? +
Very. Free carboxylate groups attract water strongly, and a thin lyophilised cake with two of them and no offsetting basic residue will take up atmospheric moisture within minutes of exposure on a humid day. The visible signs are a cake that slumps, becomes glassy, or turns to a syrup. Once that has happened the powder mass no longer corresponds to the peptide mass in it.
Chonluten and bronchogen are both named for lung tissue. Are they related? +
They are different molecules sharing a research target. Chonluten is the tripeptide Glu-Asp-Gly and bronchogen is the tetrapeptide Ala-Glu-Asp-Leu. Both were assigned to respiratory tissue within the same programme, which is what the naming reflects. It is not a chemical relationship, and neither name tells you anything about the other's sequence, mass or handling requirements.
How much independent evidence exists for chonluten? +
Very little outside the originating tradition. The publications come from a small number of connected laboratories, are largely Russian-language, and were produced over several decades under reporting conventions that differ from international peer-reviewed practice. There is no substantial body of independent replication, so specific claims about respiratory tissue should be understood as internal to that literature rather than externally corroborated.
Where does chonluten stand under Australian regulation? +
It is not registered on the ARTG. Scheduling lives in the Poisons Standard, which the TGA revises several times a year, so any statement of status is tied to a date and should be checked against the current instrument. The TGA has published a safety alert on importing unapproved peptide products and guidance on the obligations of anyone importing, compounding or supplying them. See tga.gov.au.

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